Muscle biopsy substantiates long‐term MRI alterations one year after a single dose of botulinum toxin injected into the lateral gastrocnemius muscle of healthy volunteers
Identifieur interne : 002198 ( Main/Exploration ); précédent : 002197; suivant : 002199Muscle biopsy substantiates long‐term MRI alterations one year after a single dose of botulinum toxin injected into the lateral gastrocnemius muscle of healthy volunteers
Auteurs : A. Sebastian Schroeder [Allemagne] ; Birgit Ertl-Wagner [Allemagne] ; Stefanie Britsch [Allemagne] ; J. Michael Schröder [Allemagne] ; Stefan Nikolin [Allemagne] ; Joachim Weis [Allemagne] ; Wolfgang Müller-Felber [Allemagne] ; Inga Koerte [Allemagne] ; Maximilian Stehr [Allemagne] ; Steffen Berweck [Allemagne] ; Ingo Borggraefe [Allemagne] ; Florian Heinen [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-07-30.
English descriptors
- KwdEn :
- Adult, Anti-Dyskinesia Agents (pharmacology), Biopsy (methods), Botulinum Toxins (pharmacology), Double-Blind Method, Humans, Magnetic Resonance Imaging (methods), Male, Microscopy, Electron, Transmission (methods), Middle Aged, Muscle, Skeletal (anatomy & histology), Muscle, Skeletal (drug effects), Muscle, Skeletal (ultrastructure), Prospective Studies, botulinum toxin type A (BoNT/A) injection, high signal intensity pattern, muscle MRI, muscle biopsy, long‐term neurogenic atrophy, neuromuscular junction.
- MESH :
- chemical , pharmacology : Anti-Dyskinesia Agents, Botulinum Toxins.
- anatomy & histology : Muscle, Skeletal.
- drug effects : Muscle, Skeletal.
- methods : Biopsy, Magnetic Resonance Imaging, Microscopy, Electron, Transmission.
- ultrastructure : Muscle, Skeletal.
- Adult, Double-Blind Method, Humans, Male, Middle Aged, Prospective Studies.
Abstract
Despite numerous clinical and experimental studies on botulinum toxin type A (BoNT/A), long‐term alterations of muscle texture and fine structure following BoNT/A treatment have thus far not been studied in normal human skeletal muscle. After obtaining institutional review board approval, we performed a prospective, placebo‐controlled, double‐blinded follow‐up study on two healthy adults using magnetic resonance imaging (MRI) and muscle biopsy to visualize long‐term alterations after a single BoNT/A injection into the lateral head of the gastrocnemius muscle. MRI disclosed a high‐signal‐intensity pattern in short tau inversion recovery sequences, and a reduction of the cross‐sectional area in the BoNT/A‐injected, but not in the saline‐injected contralateral control muscle (at 6 to 9 months in volunteer A: 73%, in B: 62%; at 12 months in A: 88%, and in B: 78%). Enzyme histochemistry, 12 months after injection, confirmed neurogenic atrophy of muscle fibers only in the BoNT/A‐injected muscle. Electron microscopy revealed additional degenerative changes at the neuromuscular junction. The data confirm that MRI is a suitable tool to monitor the long‐term effect of BoNT/A on skeletal muscle. Neurogenic muscle atrophy following a single BoNT/A injection should be taken into consideration when repeated BoNT/A injections into the same muscles are proposed. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22661
Affiliations:
- Allemagne
- Bavière, District de Cologne, District de Haute-Bavière, Rhénanie-du-Nord-Westphalie
- Aix-la-Chapelle, Munich
- Université Louis-et-Maximilien de Munich
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Michael Schröder</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuropathology, Medical Faculty, RWTH Aachen University, Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Nikolin, Stefan" sort="Nikolin, Stefan" uniqKey="Nikolin S" first="Stefan" last="Nikolin">Stefan Nikolin</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuropathology, Medical Faculty, RWTH Aachen University, Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name 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type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Koerte, Inga" sort="Koerte, Inga" uniqKey="Koerte I" first="Inga" last="Koerte">Inga Koerte</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Radiology, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Stehr, Maximilian" sort="Stehr, Maximilian" uniqKey="Stehr M" first="Maximilian" last="Stehr">Maximilian Stehr</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Surgery, Dr. von Hauner's Children's Hospital, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Berweck, Steffen" sort="Berweck, Steffen" uniqKey="Berweck S" first="Steffen" last="Berweck">Steffen Berweck</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Neurology and Developmental Medicine, Dr. von Hauner's Children's Hospital, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Borggraefe, Ingo" sort="Borggraefe, Ingo" uniqKey="Borggraefe I" first="Ingo" last="Borggraefe">Ingo Borggraefe</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Neurology and Developmental Medicine, Dr. von Hauner's Children's Hospital, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Heinen, Florian" sort="Heinen, Florian" uniqKey="Heinen F" first="Florian" last="Heinen">Florian Heinen</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Neurology and Developmental Medicine, Dr. von Hauner's Children's Hospital, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-07-30">2009-07-30</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1494">1494</biblScope><biblScope unit="page" to="1503">1503</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B032E1ED28CF43D1A76CEC9848F29A680D37432A</idno><idno type="DOI">10.1002/mds.22661</idno><idno type="ArticleID">MDS22661</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anti-Dyskinesia Agents (pharmacology)</term><term>Biopsy (methods)</term><term>Botulinum Toxins (pharmacology)</term><term>Double-Blind Method</term><term>Humans</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Microscopy, Electron, Transmission (methods)</term><term>Middle Aged</term><term>Muscle, Skeletal (anatomy & histology)</term><term>Muscle, Skeletal (drug effects)</term><term>Muscle, Skeletal (ultrastructure)</term><term>Prospective Studies</term><term>botulinum toxin type A (BoNT/A) injection</term><term>high signal intensity pattern</term><term>muscle MRI</term><term>muscle biopsy, long‐term neurogenic atrophy</term><term>neuromuscular junction</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Dyskinesia Agents</term><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Biopsy</term><term>Magnetic Resonance Imaging</term><term>Microscopy, Electron, Transmission</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Double-Blind Method</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite numerous clinical and experimental studies on botulinum toxin type A (BoNT/A), long‐term alterations of muscle texture and fine structure following BoNT/A treatment have thus far not been studied in normal human skeletal muscle. After obtaining institutional review board approval, we performed a prospective, placebo‐controlled, double‐blinded follow‐up study on two healthy adults using magnetic resonance imaging (MRI) and muscle biopsy to visualize long‐term alterations after a single BoNT/A injection into the lateral head of the gastrocnemius muscle. MRI disclosed a high‐signal‐intensity pattern in short tau inversion recovery sequences, and a reduction of the cross‐sectional area in the BoNT/A‐injected, but not in the saline‐injected contralateral control muscle (at 6 to 9 months in volunteer A: 73%, in B: 62%; at 12 months in A: 88%, and in B: 78%). Enzyme histochemistry, 12 months after injection, confirmed neurogenic atrophy of muscle fibers only in the BoNT/A‐injected muscle. Electron microscopy revealed additional degenerative changes at the neuromuscular junction. The data confirm that MRI is a suitable tool to monitor the long‐term effect of BoNT/A on skeletal muscle. Neurogenic muscle atrophy following a single BoNT/A injection should be taken into consideration when repeated BoNT/A injections into the same muscles are proposed. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Cologne</li><li>District de Haute-Bavière</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Aix-la-Chapelle</li><li>Munich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Schroeder, A Sebastian" sort="Schroeder, A Sebastian" uniqKey="Schroeder A" first="A. Sebastian" last="Schroeder">A. Sebastian Schroeder</name></region><name sortKey="Berweck, Steffen" sort="Berweck, Steffen" uniqKey="Berweck S" first="Steffen" last="Berweck">Steffen Berweck</name><name sortKey="Borggraefe, Ingo" sort="Borggraefe, Ingo" uniqKey="Borggraefe I" first="Ingo" last="Borggraefe">Ingo Borggraefe</name><name sortKey="Britsch, Stefanie" sort="Britsch, Stefanie" uniqKey="Britsch S" first="Stefanie" last="Britsch">Stefanie Britsch</name><name sortKey="Ertl Agner, Birgit" sort="Ertl Agner, Birgit" uniqKey="Ertl Agner B" first="Birgit" last="Ertl-Wagner">Birgit Ertl-Wagner</name><name sortKey="Heinen, Florian" sort="Heinen, Florian" uniqKey="Heinen F" first="Florian" last="Heinen">Florian Heinen</name><name sortKey="Koerte, Inga" sort="Koerte, Inga" uniqKey="Koerte I" first="Inga" last="Koerte">Inga Koerte</name><name sortKey="Muller Elber, Wolfgang" sort="Muller Elber, Wolfgang" uniqKey="Muller Elber W" first="Wolfgang" last="Müller-Felber">Wolfgang Müller-Felber</name><name sortKey="Nikolin, Stefan" sort="Nikolin, Stefan" uniqKey="Nikolin S" first="Stefan" last="Nikolin">Stefan Nikolin</name><name sortKey="Schroder, J Michael" sort="Schroder, J Michael" uniqKey="Schroder J" first="J. Michael" last="Schröder">J. Michael Schröder</name><name sortKey="Stehr, Maximilian" sort="Stehr, Maximilian" uniqKey="Stehr M" first="Maximilian" last="Stehr">Maximilian Stehr</name><name sortKey="Weis, Joachim" sort="Weis, Joachim" uniqKey="Weis J" first="Joachim" last="Weis">Joachim Weis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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